In Marvel's Spider-Man (2018), Otto mentions Dr. Karla Sofen in his lab notes. In the comics, Karla Sofen is the supervillain Moonstone, an enemy of Captain Marvel. : r/GamingDetails
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Crazy detail I found when playing the Remaster, When turning enemy visibility off in the lab, Otto disappears. I checked with the NPCs in the city and this doesn't happen to them.